반응 #2446083

반응 방정식

NaBH4

1-amino-2-propanol

cyclohexanone

→

1-(cyclohexylamino)propan-2-ol

용매

ethanol

반응 조건

후처리

1. 1
   workup.STIRRINGThe reaction mixture was stirred at rt for 15 minutes
2. 2
   기타quenched with water
3. 3
   여과The reaction mixture was filtered through a Celite® pad
4. 4
   농축the filtrate was concentrated
5. 5
   workup.DISSOLUTIONThe residue was dissolved in DCM
6. 6
   건조dried over Na2SO4
7. 7
   여과filtered
8. 8
   농축concentrated

실험 절차

To a stirred solution of 1-amino-2-propanol (1.0 mL, 13.31 mmol) in ethanol (15 mL) was added cyclohexanone (1.9 g, 19.9 mmol) at 0° C. The reaction mixture was stirred at 0° C. for 15 minutes and then NaBH4 (0.725 g, 19.17 mmol) was added. The reaction mixture was stirred at rt for 15 minutes and then quenched with water. The reaction mixture was filtered through a Celite® pad and the filtrate was concentrated. The residue was dissolved in DCM, dried over Na2SO4, filtered and concentrated to provide 1-(cyclohexylamino)propan-2-ol. Yield: 2.6 g (crude). 1H NMR (DMSO-d6) δ 4.39-4.36 (m, 1 H), 3.61-3.57 (m, 1 H), 2.47-2.30 (m, 3 H), 1.78-1.75 (m, 2 H), 1.66-1.63 (m, 2 H), 1.55-1.52 (m, 1 H), 1.23-1.12 (m, 3 H), 1.03-0.89 (m, 5 H). 1-(cyclohexylamino)propan-2-ol may also be prepared by following procedure of Example 1.

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