반응 #2446067

반응 방정식

t-BuOK

→

1-(3-propylcyclopentyl)-4-vinylcyclohexane

용매

THF

THF

THF

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   추출was extracted with toluene
3. 3
   workup.ADDITIONafter the addition of water (50 ml)
4. 4
   세척The resulting organic layer was washed with water
5. 5
   건조dried over anhydrous sulfate
6. 6
   농축the solution was concentrated under reduced pressure to a volume of about 50 ml
7. 7
   workup.ADDITIONThe concentrate was poured into n-hexane (200 ml) and solids
8. 8
   여과deposited were filtered off
9. 9
   workup.DISTILLATIONThe solvent of the resulting solution was distilled off under reduced pressure
10. 10
    기타the residue was purified by silica gel chromatography (eluent: n-heptane)
11. 11
    기타purified by means of a preparative HPLC system, Model PLC-561

실험 절차

THF (50 ml) was added to methyltriphenylphosphonium bromide (6.27 g) in a reaction vessel under an atmosphere of nitrogen, and the mixture was cooled to −15° C. t-BuOK (1.97 g) in a THF (20 ml) solution was added, and the stirring was continued for another 1 hour. 4-(3-Propylcyclopentyl)-cyclohexanone4-(3-propylcyclopentyl)cyclohexanecarboaldehyde (3.0 g) in a THF (20 ml) solution was added dropwise and the mixture was stirred for another 2 hours. The reaction mixture was warmed to room temperature and was extracted with toluene after the addition of water (50 ml). The resulting organic layer was washed with water and dried over anhydrous sulfate, and the solution was concentrated under reduced pressure to a volume of about 50 ml. The concentrate was poured into n-hexane (200 ml) and solids deposited were filtered off. The solvent of the resulting solution was distilled off under reduced pressure, and the residue was purified by silica gel chromatography (eluent: n-heptane) and then purified by means of a preparative HPLC system, Model PLC-561 made by GL Sciences Inc. to give 1-(3-propylcyclopentyl)-4-vinylcyclohexane (2.0 g).

출처