반응 #2439940

반응 방정식

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

4-(4-methyl-piperazin-1-yl)-phenylamine

→

title compound

수율 57.0%

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-{[4-(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

수율 57.0%

용매

THF

반응 조건

후처리

1. 1
   기타A small screw cap test tube
2. 2
   온도Subsequently, the reaction mixture was cooled to room temperature
3. 3
   농축The reaction mixture was concentrated in vacuo
4. 4
   기타purified via flash silica gel chromatography (5% MeOH/95% CHCl3)

실험 절차

A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide (as prepared in Example 1, 30 mg, 0.072 mmol) and THF (1 mL). To the resulting solution was added 4-(4-methyl-piperazin-1-yl)-phenylamine (20.7 mg, 0.1082 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. The reaction mixture was concentrated in vacuo and purified via flash silica gel chromatography (5% MeOH/95% CHCl3) providing the title compound in 57% yield (24 mg, 0.0407 mmol).

출처