반응 #2439926

반응 방정식

2-(p-fluorophenyl)-4-methyl-pyridine

N-bromosuccinimide

benzoylperoxide

→

2-(p-fluorophenyl)-4-bromomethyl-pyridine

수율 88.7%

용매

CCl4

반응 조건

후처리

1. 1
   온도at reflux temperature
2. 2
   기타irradiated by means of an ordinary 250-W UV lamp for 4 hrs
3. 3
   온도Afterwards, the reaction mixture was cooled
4. 4
   기타subsequently triturated with Et2O/petroleum benzine
5. 5
   기타The precipitate was removed by filtration
6. 6
   농축the filtrate was concentrated in vacuo

실험 절차

A mixture of 2-(p-fluorophenyl)-4-methyl-pyridine (0.5 g, 2.67 mmol), N-bromosuccinimide (0.48 g, 2.69 mmol), and a catalytic amount of benzoylperoxide in CCl4 (50 ml) was stirred at reflux temperature and irradiated by means of an ordinary 250-W UV lamp for 4 hrs. Afterwards, the reaction mixture was cooled and subsequently triturated with Et2O/petroleum benzine. The precipitate was removed by filtration, and the filtrate was concentrated in vacuo to give 2-(p-fluorophenyl)-4-bromomethyl-pyridine (0.63 g, 88%, unstable) as a dark yellow oil.

출처