반응 #2439

반응 방정식

2-n-butyl-4-chloro-5-hydroxymethylimidazole

water

→

aldehyde

수율 86.3%

2-n-Butyl-4-chloro-5-imidazolecarboxaldehyde

수율 86.3%

용매

methylene chloride

반응 조건

후처리

1. 1
   온도was refluxed for 24 h
2. 2
   여과The mixture was filtered hot through a Celite® pad
3. 3
   세척The Celite® pad was washed several times with hot methylene chloride
4. 4
   농축concentrated in vacuo

실험 절차

A stirred mixture of 2-n-butyl-4-chloro-5-hydroxymethylimidazole (15.00 g, 0.0795 mol) and activated manganese dioxide (40.00 g) in 600 ml of methylene chloride was refluxed for 24 h using a water separator. The mixture was filtered hot through a Celite® pad. The Celite® pad was washed several times with hot methylene chloride. The washings were combined with the filtrate and concentrated in vacuo to give 12.81 g (86%) of the aldehyde as a white solid; mp 97°-98° C.

출처