반응 #2438

반응 방정식

p-Toluenesulfonyl chloride

glycerol

HCl

→

Compound 2

Glycerol-1,3-ditosylate

용매

pyridine

pyridine

반응 조건

후처리

1. 1
   기타Compound 2 was synthesized
2. 2
   workup.ADDITIONThe solution was added slowly
3. 3
   workup.WAITleft
4. 4
   기타to react for 44 hours in the refrigerator (0°-3° C.)
5. 5
   workup.ADDITIONThe pink mixture was poured
6. 6
   기타over crushed ice
7. 7
   기타The organic layer was separated
8. 8
   세척the aqueous layer was washed with methylene chloride (2×50 ml)
9. 9
   세척The combined organic extracts were washed successively with 2N HCl (2×10 ml)
10. 10
    workup.DISTILLATIONdistilled water (2×10 ml)
11. 11
    건조dried over anhydrous Na2SO4
12. 12
    기타The filtrate was evaporated
13. 13
    기타the residual crude product was purified by column chromatography on silica gel

실험 절차

Compound 2 was synthesized according to the previous reported method with modifications (Benbouzid et al., 1988). p-Toluenesulfonyl chloride (10.29 g, 54 mmol) dissolved in dry pyridine was added to a stirred solution of anhydrous glycerol (2.48 g, 27 mmol) in dry pyridine (30 ml at 0° C.). The solution was added slowly and left to react for 44 hours in the refrigerator (0°-3° C.). The pink mixture was poured over crushed ice and acidified with concentrated HCl. The organic layer was separated and the aqueous layer was washed with methylene chloride (2×50 ml). The combined organic extracts were washed successively with 2N HCl (2×10 ml) and distilled water (2×10 ml) and dried over anhydrous Na2SO4. The filtrate was evaporated and the residual crude product was purified by column chromatography on silica gel to afford Compound 2 as an oil: 9.72 g (24.3 mmol) yield 90%. 1H NMR [Chemical shift (d), multiplicity, coupling constant (Hz), number of protons, atom]: 7.75 (d; J=8.2 Hz; 4H, Har.); 7.35 (d; J=8.2 Hz; 4H; Har.); 4.1 (bs; 4H; H1,3); 3.35 (bs; 1H; H2); 2.4 (s; 6H; 2CH3). 13C NMR (ppm): 145 (C ar.); 131.7 (C ar.); 129.7 (CH ar.); 127.6 (CH ar.); 69.3 (C1,3); 66.7 (C2); 21.2 (CH3). Satisfactory 1H and 13C NMR data as well as mass spectral data were recorded for this compound. These spectra were consistent with the structures shown in FIG. 1.

출처