반응 #2432

반응 방정식

compound

Methyl 3-(2-oxo-1-piperidinyl)benzoate

borane tetrahydrofuran

→

oil

수율 90.0%

Methyl 3-(1-piperidinyl)benzoate

수율 90.0%

용매

THF

반응 조건

후처리

1. 1
   온도under reflux for 1 h
2. 2
   온도cooled
3. 3
   기타evaporated
4. 4
   온도heated
5. 5
   온도under reflux for 3 h
6. 6
   기타evaporated
7. 7
   기타chromatographed (eluant 10% EtOAc in hexanes)

실험 절차

The compound of Example 37 (640 mg, 2.75 mmol) was dissolved in dry THF (30 ml) and borane-tetrahydrofuran complex (5 ml, 1M solution in THF) was added. The mixture was stirred under nitrogen under reflux for 1 h, then cooled and evaporated. The residue was taken up in MeOH/acetic acid (6/1, v/v, 70 ml) and heated under reflux for 3 h, then evaporated and chromatographed (eluant 10% EtOAc in hexanes) to provide a colourless oil (540 mg, 90%).

출처