반응 #2412

반응 방정식

ammonium chloride

4-tert-butylbenzenesulfonyl chloride

5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]pyrimidine-4-amine

sodium hydride

→

N-{5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]-pyrimidin-4-yl}-4-tert-butylbenzenesulfonamide

수율 85.5%

용매

water

pyridine

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.STIRRINGThe mixture is stirred at room temperature for 30 minutes
2. 2
   추출The mixture is extracted with ethyl acetate
3. 3
   세척the ethyl acetate layer is washed
4. 4
   기타dried
5. 5
   기타evaporated
6. 6
   기타to remove the solvent
7. 7
   기타The residue is purified by preparative thin layer chromatography (solvent; chloroform/methanol=15:1)
8. 8
   기타recrystallized from hexane/ethyl acetate

실험 절차

To a solution of 5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]pyrimidine-4-amine (102 mg) in tetrahydrofuran (2 ml) is added sodium hydride (60% dispersion-type, 34 mg), and thereto is added 4-tert-butylbenzenesulfonyl chloride (198 mg). The mixture is stirred at room temperature for 20 minutes, and thereto are added a drop of pyridine and water. The mixture is stirred at room temperature for 30 minutes, and neutralized with saturated aqueous ammonium chloride solution. The mixture is extracted with ethyl acetate, and the ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is purified by preparative thin layer chromatography (solvent; chloroform/methanol=15:1), and recrystallized from hexane/ethyl acetate to give N-{5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]-pyrimidin-4-yl}-4-tert-butylbenzenesulfonamide (135 mg). The physical properties thereof are the same as those of the compound obtained in Reference Example 16-(4).

출처