반응 #2410

반응 방정식

2-(6-aminopyrimidin-4-yloxy)ethanol

bromine

→

2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol

수율 104.7%

용매

methanol

methanol

반응 조건

후처리

1. 1
   기타The mixture is evaporated
2. 2
   기타to remove the solvent
3. 3
   workup.DISSOLUTIONthe residue is dissolved in ethyl acetate
4. 4
   workup.ADDITIONThe mixture is treated with saturated aqueous sodium hydrogen carbonate solution
5. 5
   추출extracted with ethyl acetate/tetrahydrofuran
6. 6
   세척The organic layer is washed
7. 7
   기타dried
8. 8
   기타evaporated
9. 9
   기타to remove the solvent

실험 절차

To a suspension of 2-(6-aminopyrimidin-4-yloxy)ethanol (400 mg) in methanol (4 ml) is added dropwise a solution of bromine (437 mg) in methanol (2 ml). The mixture is evaporated to remove the solvent, and the residue is dissolved in ethyl acetate. The mixture is treated with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate/tetrahydrofuran. The organic layer is washed, dried, and evaporated to remove the solvent to give 2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol (632 mg).

출처