반응 #2409

반응 방정식

2-(6-azidopyrimidin-4-yloxy)ethanol

→

2-(6-aminopyrimidin-4-yloxy)ethanol

수율 79.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타The catalyst is removed by filtration
2. 2
   농축the filtrate is concentrated
3. 3
   기타The residue is recrystallized from ethanol/diethyl ether

실험 절차

A mixture of 2-(6-azidopyrimidin-4-yloxy)ethanol (1.64 g), 10% palladium-carbon (0.25 g) and ethanol (20 ml) is subjected to catalytic hydrogenation at room temperature for one hour under hydrogen atmosphere (1 atm). The catalyst is removed by filtration, and the filtrate is concentrated. The residue is recrystallized from ethanol/diethyl ether to give 2-(6-aminopyrimidin-4-yloxy)ethanol (1.11 g).

출처