반응 #2407
ord-f570953042144533ac7122491f64e455
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도cooling
- 2기타evaporated
- 3기타to remove the solvent
- 4추출The residue is extracted with ethyl acetate
- 5추출the ethyl acetate extract
- 6기타is dried
- 7농축concentrated under reduced pressure
- 8기타The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1)
실험 절차
To a mixture of 4,6-dichloropyrimidine (5.0 g), ethylene glycol (100 ml) and tetrahydrofuran (100 ml)is added sodium hydride (60% dispersion-type, 1.34 g) under ice-cooling. The mixture is stirred at the same temperature for two hours, and evaporated to remove the solvent. The residue is extracted with ethyl acetate, and the ethyl acetate extract is dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1) to give 2-(6-chloropyrimidin-4-yloxy)ethanol (5.67 g) as an oily product.