반응 #2404

반응 방정식

4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide

sodium hydride

ethylene glycol

hydrochloric acid

→

4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The ethyl acetate layer is washed
4. 4
   기타dried
5. 5
   기타evaporated
6. 6
   기타to remove the solvent
7. 7
   기타The residue is crystallized from ethyl acetate

실험 절차

To ethylene glycol (20 ml) is added sodium hydride (60% dispersion-type, 1.03 g), and thereto is added 4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide (1.66 g). The mixture is stirred at 60° C. for 20 hours. After cooling, the mixture is acidified with 10% hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from ethyl acetate to give 4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide (1.58 g).

출처