반응 #2403

반응 방정식

4,6-dichloropyrimidine

4-tert-butylbenzenesulfonamide

sodium hydride

→

4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide

수율 69.4%

용매

hydrochloric acid

water

dimethylformamide

반응 조건

후처리

1. 1
   추출The mixture is extracted with ethyl acetate
2. 2
   세척the ethyl acetate layer is washed
3. 3
   기타dried
4. 4
   기타evaporated
5. 5
   기타to remove the solvent
6. 6
   기타The residue is recrystallized from ethyl acetate

실험 절차

To a solution of 4,6-dichloropyrimidine (1.33 g) and 4-tert-butylbenzenesulfonamide (1.96 g) in dimethylformamide (20 ml) is added sodium hydride (60% dispersion-type, 714 mg). The mixture is stirred at room temperature for two hours, and the reaction solution is diluted with 10% hydrochloric acid and water. The mixture is extracted with ethyl acetate, and the ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is recrystallized from ethyl acetate to give 4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide (2.02 g).

출처