반응 #2400

반응 방정식

4,6-dichloro-5-(4-methylphenyl)pyrimidine

ammonia ethanol

→

6-chloro-5-(4-methylphenyl)pyrimidin-4-amine

용매

ether

반응 조건

후처리

1. 1
   기타the reaction mixture is reacted at room temperature in a sealed tube for three days
2. 2
   농축The mixture is concentrated under reduced pressure
3. 3
   기타the residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=(10:1)~ethyl acetate)

실험 절차

To a solution of 4,6-dichloro-5-(4-methylphenyl)pyrimidine (4.14 g) in ether (20 ml) is added 27% ammonia-ethanol solution (30 ml), and the reaction mixture is reacted at room temperature in a sealed tube for three days. The mixture is concentrated under reduced pressure, and the residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=(10:1)~ethyl acetate) to give 6-chloro-5-(4-methylphenyl)pyrimidin-4-amine (1.89 g).

출처