반응 #2399

반응 방정식

2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

→

2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

수율 89.7%

용매

ethanol

반응 조건

후처리

1. 1
   기타is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere
2. 2
   기타for one hour
3. 3
   기타The catalyst is removed by filtration
4. 4
   농축the filtrate is concentrated under reduced pressure
5. 5
   기타The residue is recrystallized from ethyl acetate/n-hexane

실험 절차

A mixture of 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (19.6 g), 10% palladium-carbon (50% moist) (4.0 g) and ethanol (240 ml) is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere (1 atm) for one hour. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is recrystallized from ethyl acetate/n-hexane to give 2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (15.9 g).

출처