반응 #2398

반응 방정식

2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

sodium azide

dimethyformamide

→

2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

수율 87.5%

용매

water

반응 조건

후처리

1. 1
   온도is heated
2. 2
   온도After cooling
3. 3
   추출extracted with ethyl acetate
4. 4
   세척The ethyl acetate layer is washed
5. 5
   기타dried
6. 6
   기타evaporated
7. 7
   기타to remove the solvent
8. 8
   기타The residue is crystallized from hexane

실험 절차

A mixture of 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (21.85 g), sodium azide (10.7 g) and dimethyformamide (260 ml) is heated with stirring at 75°-80° C. overnight. After cooling, the mixture is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane to give 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g).

출처