반응 #2375507

ord-a16bf6cb181e43a283dac1913b5bf446

반응 방정식

CCO.CCOC(C)=O.N
ethyl acetate ethanol ammonia
COC(=O)CCN(C(=O)c1cnc2c(c1)nc(CCc1ccc(C#N)cc1)n2C)c1ccccn1
3-methyl-2-[2-(4-cyanophenyl)ethyl]-imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)-amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate
→
COC(=O)CCN(C(=O)c1cnc2c(c1)nc(CCc1ccc(C(=N)N)cc1)n2C)c1ccccn1.Cl
3-Methyl-2-[2-(4-amidinophenyl)ethyl]-imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)-amide-hydrochloride
수율 75.0%

반응물

—
C26H27N7O3
CCO.CCOC(C)=O.N
ethyl acetate ethanol ammonia
COC(=O)CCN(C(=O)c1cnc2c(c1)nc(CCc1ccc(C#N)cc1)n2C)c1ccccn1
3-methyl-2-[2-(4-cyanophenyl)ethyl]-imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)-amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate

시약

없음

용매

CO
methanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Prepared analogously to Example 1 from 3-methyl-2-[2-(4-cyanophenyl)ethyl]-imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)-amide, methanolic hydrochloric acid, methanol and ammonium carbonate. Yield: 75% of theory, C26H27N7O3 (485.55) Rf value: 0.31 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5) EKA mass spectrum: (M+H)+ =486

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06087380uspto-grants-2000_07