반응 #2368121

반응 방정식

Compound 106

2-(2-chloro-5-methylpyrimidine-4-ylamino)-N-(1-(cyclopropylmethyl)piperidine-4-yl)-N-methylacetamide

4-methoxybenzylamine

diisopropylethylamine

→

desired product

수율 36.0%

N-(1-(cyclopropylmethyl)piperidine-4-yl)-2-(2-(4-methoxybenzylamino)-5-methylpyrimidine-4-ylamino)-N-methylacetamide

수율 36.0%

용매

n-butanol

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   농축Subsequently, the reaction mixture was concentrated under reduced pressure
3. 3
   기타the resulting residue was purified by silica gel column chromatography (methylene chloride:methanol=50:1 to 4:1)

실험 절차

A solution of Compound 106 (93 mg), 4-methoxybenzylamine (345 μL) and diisopropylethylamine (45.5 μL) in n-butanol (1.5 mL) was stirred overnight under reflux. Subsequently, the reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (methylene chloride:methanol=50:1 to 4:1) to give 43 mg (36% yield) of the desired product as a white amorphous.

출처