반응 #2364528

반응 방정식

2-(6-bromo-1-fluorocarbazol-9-yl)phenylamine

NaH

→

3-Bromo-8H-8,12b-diazabenzo[a]aceanthrylene

용매

DMF

반응 조건

후처리

1. 1
   workup.ADDITIONare added at room temperature
2. 2
   온도under reflux for 6 h
3. 3
   기타the solvent is removed
4. 4
   기타the residue is purified by chromatography

실험 절차

25 g (72 mmol) of 2-(6-bromo-1-fluorocarbazol-9-yl)phenylamine are dissolved in 200 ml of DMF under a protective gas, 2.8 g (72 mmol) of NaH (60% in oil) are added at room temperature, and the mixture is boiled under reflux for 6 h. The mixture is subsequently warmed to room temperature over the course of 1 h, the solvent is removed, and the residue is purified by chromatography.

출처