반응 #2361905

반응 방정식

1

5-(1H-benzo[d]imidazol-6-yl)-1,3,4-oxadiazole-2-thiol

allylbromide

→

5-(5-(Allylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazole

용매

EtOH

반응 조건

후처리

1. 1
   온도under reflux overnight
2. 2
   기타The solvent was removed
3. 3
   기타the remaining oil was purified by flash-chromatography on silica gel

실험 절차

1 (0.33 g, 1.5 mmol), TEA (0.209 mL, 1.5 mmol) and allylbromide (0.093 mL, 1.5 mmol) were dissolved in 10 mL of EtOH and kept under reflux overnight. The solvent was removed and the remaining oil was purified by flash-chromatography on silica gel, applying a CHCl3/MeOH gradient.

출처