반응 #2358562

반응 방정식

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H) thione

dimethylaminopropylamine

→

title compound

수율 85.1%

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-9-(3-dimethylaminopropyl)imino-10-methyl-(9H,10H)-acridine

수율 85.1%

용매

pyridine

반응 조건

후처리

1. 1
   기타Solvent was partially evaporated
2. 2
   기타reaction product
3. 3
   기타was precipitated by addition of methanol
4. 4
   여과Precipitate was collected by filtration
5. 5
   세척washed with methanol
6. 6
   기타dried

실험 절차

A mixture of 2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H) thione (145 mg, 0.25 mmole), pyridine (5 mL) and dimethylaminopropylamine (0.125 mL, 1 mmole) was stirred at 100° C. for 4 hrs. Solvent was partially evaporated and reaction product was precipitated by addition of methanol. Precipitate was collected by filtration, washed with methanol and dried to give 137 mg (85%) of the title compound. MS 644 (MH+).

출처