반응 #2358561

반응 방정식

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione

hydroxylamine hydrochloride

→

title compound

수율 85.3%

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-9-hydroxyimino-10-methyl-(9H,10H)-acridine

수율 85.3%

용매

pyridine

반응 조건

후처리

1. 1
   기타Solvent was removed
2. 2
   workup.ADDITIONthe residue was treated with water
3. 3
   기타to remove excess of hydroxylamine
4. 4
   기타Crude material was crystallized from methanol-water

실험 절차

To a solution of 2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione (290 mg, 0.5 mmole) in pyridine (5 mL) was added hydroxylamine hydrochloride (210 mg, 30 mmole) and the mixture was stirred at 100° C. for 8 hrs. Solvent was removed and the residue was treated with water to remove excess of hydroxylamine. Crude material was crystallized from methanol-water to give 245 mg (85%) of the title compound. MS 575 (MH+).

출처