반응 #2358549

반응 방정식

compound ( 4 )

5-(2-(benzyloxy)-5-isopropyl-4-(methoxymethoxy)phenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol

HCl

→

5-(2-(benzyloxy)-4-hydroxy-5-isopropylphenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol hydrochloride

수율 74.0%

용매

MeOH

반응 조건

후처리

1. 1
   온도cooled
2. 2
   기타The white precipitate thus obtained
3. 3
   여과was filtered
4. 4
   세척washed with ether (2×20 ml)

실험 절차

To the solution of compound (4) (2.10 g, 3.95 mmol) in MeOH (100 ml), HCl (2 ml, 2N) was added, and then the resultant mixture was heated at 65° C. for 5 h, then cooled. The white precipitate thus obtained was filtered, washed with ether (2×20 ml) gave 1.53 g (74%) of 5-(2-(benzyloxy)-4-hydroxy-5-isopropylphenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol hydrochloride (5).

출처