반응 #2358543

반응 방정식

(S)-3-((R)-1-hydroxy-2-methylpropyl)pyrrolidine-1-carboxylic acid t-butyl ester

p-chlorophenol

Diisopropyl azodicarboxylate

triphenylphosphine

→

(S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine-1-carboxylic acid t-butyl ester

수율 10.8%

용매

—

Hexanes

—

hexanes

2-methyl-tetrahydrofuran

반응 조건

후처리

1. 1
   기타the vessel purged with nitrogen
2. 2
   workup.STIRRINGthe resulting mixture was stirred at room temperature for 30 minutes
3. 3
   기타The phases were separated
4. 4
   세척the organic layer was washed with 1.0 M NaOH in water (600 mL)
5. 5
   세척washed with diluted saturated aqueous NaCl (20 mL)
6. 6
   건조dried over Na2SO4
7. 7
   기타to yield the crude BOC-
8. 8
   workup.STIRRINGthe resulting mixture was stirred for 30 minutes
9. 9
   여과Solids were filtered off
10. 10
    기타to yield the crude BOC-
11. 11
    기타was then purified by silica gel chromatography (0-10-20% EtOAc in hexanes)

실험 절차

(S)-3-((R)-1-hydroxy-2-methylpropyl)pyrrolidine-1-carboxylic acid t-butyl ester (35.0 g, 144 mmol, 1.0 eq.), triphenylphosphine (41.5 g, 158 mmol, 1.1 eq.), p-chlorophenol (37.0 g, 288 mmol, 2.0 eq.) and 2-methyl-tetrahydrofuran (300 mL) were combined and the vessel purged with nitrogen. Diisopropyl azodicarboxylate (31.2 mL, 1.1 eq.) was added slowly at room temperature over 2 hours. The mixture was then stirred at room temperature overnight. Hexanes (600 mL) were added and the resulting mixture was stirred at room temperature for 30 minutes. The phases were separated and the organic layer was washed with 1.0 M NaOH in water (600 mL), washed with diluted saturated aqueous NaCl (20 mL), then dried over Na2SO4 to yield the crude BOC-protected intermediate. Additional hexanes (50 mL) were added and the resulting mixture was stirred for 30 minutes. Solids were filtered off to yield the crude BOC-protected intermediate as a thick oil, which was then purified by silica gel chromatography (0-10-20% EtOAc in hexanes) to yield (S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine-1-carboxylic acid t-butyl ester (5.5 g).

출처