반응 #2358540
ord-ce4439f8ff9245c884c3403f8846569b
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후처리
- 1기타Compounds of formula I in free form and in single stereoisomeric form thus obtained may
- 2workup.ADDITIONbe converted into a salt by addition of an acid to the free base of a compound of formula I
- 3workup.DISSOLUTIONE.g. a compound of formula I may be dissolved
- 4기타is obtained
- 5workup.DISSOLUTIONin dissolved
실험 절차
Compounds of formula I in free form and in single stereoisomeric form thus obtained may be converted into a salt by addition of an acid to the free base of a compound of formula I. E.g. a compound of formula I may be dissolved or suspended, or is obtained in dissolved or suspended form, in organic solvent, preferably a solvent or solvent mixture, such as an alcohol, e.g. methanol, ethanol; a halogenated hydrocarbon, e.g. dichloromethane; an ether, e.g. tetrahydrofuran, an acetate, such as methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate; a solvent mixture of alcohol with acetate, such as methanol/isopropyl acetate, a solvent mixture of halogenated hydrocarbon with acetate, such as dichloromethane/isopropylacetate, a solvent mixture of ether with acetate, such as tetrahydrofuran/isopropyl acetate, and to the mixture obtained an acid, e.g. an organic acid or an inorganic (mineral) acid, e.g. acetic acid, lactic acid, e.g. L-lactic acid, maleic acid, is added. A compound of formula I, in the form of a salt, e.g. crystalline salt, may be obtained and may be isolated.