반응 #2358525

반응 방정식

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

HCl

NaOH

→

title compound

수율 78.6%

2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethanamine

수율 78.6%

용매

EtOH

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate (2×100 ml)
2. 2
   세척The combined organic phase was washed with brine (75 ml)
3. 3
   건조dried (Na2SO4)
4. 4
   기타evaporated

실험 절차

A mixture of tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate (1.4 g, 4.2 mmol) in EtOH (18 ml) was added HCl (1.25 M in EtOH, 6 ml). The mixture was stirred at ambient temperature for 20 h. The aqueous phase was made basic by addition of aqueous NaOH (1 M, 50 ml) and extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with brine (75 ml), dried (Na2SO4) and evaporated to yield the title compound (0.77 g, 77%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

출처