반응 #2358509

반응 방정식

hydrochloric acid

1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene

ethanamine

→

N-ethyl-2-(3-fluoro-5-methylsulfonyl-phenoxy)ethanamine

용매

ethanol

반응 조건

후처리

1. 1
   기타Preparation
2. 2
   기타re-crystallized from ethanol/diethyl ether

실험 절차

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene (0.321 g, 1.08 mmol) and ethanamine (4.3 ml, 8.6 mmol 2 M in methanol) in ethanol (6 ml). Yield: 255 mg (90%). The amine was converted to the hydrochloric acid salt and re-crystallized from ethanol/diethyl ether: M.p. 200.8-201.1° C. MS m/z (relative intensity, 70 eV) 261 (M+, 3), 94 (6), 59 (12), 58 (bp), 56 (8).

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