반응 #2358499

ord-93119d74154f46c3a6e359a34f56ebb6

반응 방정식

COC(=O)C(c1ccccc1)C1CCCCN1.Cl
methylphenidate HCl
COC(=O)C(c1ccccc1)C1CCCCN1
Methylphenidate

시약

없음

용매

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The wet pellets are dried (Fluid Air Model#0050)
  2. 2
    여과sieved (30 mesh<Acceptable<20 mesh)

실험 절차

In a preferred manufacturing process, methylphenidate HCl and microcrystalline cellulose (Avicel PH-101) are blended in a Hobart Mixer. Purified water is added to the dry mixture and the wet granulation is extruded (MG-55 Multi granulator). The extrudate is then spheronized into pellets (Caleva Model#SPH250). The wet pellets are dried (Fluid Air Model#0050) and sieved (30 mesh<Acceptable<20 mesh).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09119809B2uspto-grants-2015_09