반응 #2355152

반응 방정식

1,5-dichloropentan-3-one

trifluoroacetic acid

sodium trifluoroacetate

→

1,5-bis(trifluoroacetoxy)pentan-3-one

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   workup.ADDITIONwas poured
3. 3
   기타over crushed ice
4. 4
   추출a product of 1,5-bis(trifluoroacetoxy)pentan-3-one was extracted with dichloromethane
5. 5
   건조After drying with MgSO4
6. 6
   여과filtering
7. 7
   기타removal of the solvent

실험 절차

A mixture of 17.85 g of 1,5-dichloropentan-3-one, 92 mL of trifluoroacetic acid, and 34.55 g of sodium trifluoroacetate was stirred and heated at 75° C. for 64 hours. The mixture was allowed to cool to room temperature, was poured over crushed ice, and a product of 1,5-bis(trifluoroacetoxy)pentan-3-one was extracted with dichloromethane. After drying with MgSO4, filtering, and removal of the solvent, 24.4 g of crude 1,5-bis(trifluoroacetoxy)pentan-3-one product was obtained. Analysis of the 1,5-bis(trifluoroacetoxy)pentan-3-one showed 1HNMR (CDCl3, TMS ref.): 2.94 (t, 4H), 4.63 (t, 4H) ppm.

출처