반응 #2355150

반응 방정식

1-(2-fluoroethyl)-4-(4-methylphenyl)-1,2,3,5-(1H)-tetrazole

N-bromosuccinimide

benzoyl peroxide

→

4-[1-(2-fluoroethyl)-1,2,3,5-(1H)-tetrazol-4-yl]benzyl bromide

수율 15.9%

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   온도Once at reflux the reaction mixture
2. 2
   기타After this time the heat source was removed
3. 3
   workup.STIRRINGthe reaction mixture was stirred for about 18 hours
4. 4
   여과At the conclusion of this period the reaction mixture was filtered
5. 5
   농축the filtrate was concentrated under reduced pressure

실험 절차

Under a light source a stirred solution of 2.8 grams (0.013 mole) of 1-(2-fluoroethyl)-4-(4-methylphenyl)-1,2,3,5-(1H)-tetrazole, 2.4 grams (0.013 mole) of N-bromosuccinimide, and 0.19 gram (0.0008 mole) of benzoyl peroxide in 100 mL of carbon tetrachloride was heated to reflux. Once at reflux the reaction mixture was stirred for five hours. After this time the heat source was removed and the reaction mixture was stirred for about 18 hours. At the conclusion of this period the reaction mixture was filtered, and the filtrate was concentrated under reduced pressure, yielding 0.59 gram of 4-[1-(2-fluoroethyl)-1,2,3,5-(1H)-tetrazol-4-yl]benzyl bromide. The NMR spectrum was consistent with the proposed structure.

출처