반응 #2355138

반응 방정식

(2-chlorophenyl)(4-chlorophenyl)methanol

thionyl chloride

→

(2-chlorophenyl)(4-chlorophenyl)methyl chloride

수율 102.3%

용매

chloroform

반응 조건

후처리

1. 1
   workup.ADDITIONUpon completion of the addition the reaction mixture
2. 2
   여과After this time the reaction mixture was filtered
3. 3
   농축concentrated under reduced pressure
4. 4
   농축concentrated under reduced pressure

실험 절차

A stirred solution of 9.0 grams (0.036 mole) of (2-chlorophenyl)(4-chlorophenyl)methanol in 90 mL of chloroform was cooled to 0° C., and 5.3 mL (0.072 mole) of thionyl chloride was added. Upon completion of the addition the reaction mixture was allowed to warm to ambient temperature, where it stirred for about 18 hours. After this time the reaction mixture was filtered and concentrated under reduced pressure. The filtrate was taken up in hexane and subjected to column chromatography on silica gel with hexane as eluant. The product-containing fractions were combined and concentrated under reduced pressure, yielding 10.0 grams of (2-chlorophenyl)(4-chlorophenyl)methyl chloride. The NMR spectrum was consistent with the proposed structure.

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