반응 #2353271

반응 방정식

2-(6-isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-4-methoxy-but-2-enenitrile

guanidine carbonate

sodium methoxide

HCl

→

5-(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-pyrimidine-2,4-diamine

용매

ethanol

Diethyl ether

diethyl ether

반응 조건

후처리

1. 1
   기타formed
2. 2
   기타The solid that had formed
3. 3
   여과was collected by filtration
4. 4
   세척washed with diethyl ether
5. 5
   기타dried under vacuum at 45 C
6. 6
   기타to give 171 mg

실험 절차

5-(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-pyrimidine-2,4-diamine was prepared from 2-(6-isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-4-methoxy-but-2-enenitrile by treatment with guanidine carbonate and sodium methoxide using the procedure of step 7 of Example 2 above. This material was dissolved in 2.5 ml absolute ethanol, and 820 ml of 1 N HCl in diethyl ether was added with stirring. Diethyl ether was added slowly until small crystals formed, and the solution was then placed in a −10 C freezer for 18 hours. The solid that had formed was collected by filtration, washed with diethyl ether, and dried under vacuum at 45 C to give 171 mg. of the hydrochloride salt, Mp: 185.1° C.

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