반응 #2351863

반응 방정식

1-(4-Methoxyphenyl)-2-methyl-1H-indole

Boron tribromide

→

4-(2-Methylindol-1-yl)phenol

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The reaction was quenched by addition of saturated sodium bicarbonate solution
2. 2
   추출extracted with dichloromethane
3. 3
   건조The organic extracts were dried over MgSO4
4. 4
   농축concentrated

실험 절차

1-(4-Methoxyphenyl)-2-methyl-1H-indole (175 mg, 0.73 mmol) was dissolved in dichloromethane (2 mL) and cooled to 0° C. Boron tribromide (2.19 mL, 1 M solution in dichloromethane, 2.19 mmol) was added dropwise, and the reaction was stirred for 2 hours. The reaction was quenched by addition of saturated sodium bicarbonate solution, then extracted with dichloromethane followed by ethyl acetate. The organic extracts were dried over MgSO4 and concentrated. The reaction was assumed to be quantitative. LC-MS (C15H13NO calc'd 223) m/z 224 (M+H).

출처