반응 #2348102

반응 방정식

hydrogen

compound ( 24 )

2-(4-propylphenyl)ethenyl-2,3-difluoro-4-(4-pentylphenyl)toluene

→

2-(4-propylphenyl)ethyl-2,3-difluoro-4-(4-pentylphenyl)toluene

수율 60.3%

용매

toluene

반응 조건

후처리

1. 1
   기타was not absorbed
2. 2
   기타Pd/C was removed by filtration
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   기타The residue was purified by silica gel column chromatography and recrystallization

실험 절차

0.33 g of Pd/C was added to 6.50 g of the compound (24) having been dissolved in 100 mL of toluene and 100 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed by filtration, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 3.94 g of 2-(4-propylphenyl)ethyl-2,3-difluoro-4-(4-pentylphenyl)toluene (Compound 1-2-3-3) as colorless crystals.

출처