반응 #2348088

반응 방정식

hydrochloric acid

sec-BuLi

compound ( 2 )

2,3-difluorotoluene

THF

trimethyl borate

THF

→

2,3-difluoro-5-methylphenylboric acid

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   workup.ADDITIONwas added dropwise
3. 3
   workup.STIRRINGby stirring at the same temperature for 1 hour
4. 4
   workup.STIRRINGstirred over night
5. 5
   온도Under cooling with an ice bath
6. 6
   추출The aqueous layer was extracted with diethyl ether, which
7. 7
   workup.ADDITIONwas added to the organic layer
8. 8
   세척the organic layer was washed with a saturated saline
9. 9
   건조dried over anhydrous magnesium sulfate
10. 10
    workup.DISTILLATIONThe solvent was distilled off

실험 절차

Under a nitrogen atmosphere, 30 g the compound (2) having been dissolved in 240 mL of THF was cooled to −78° C., to which 284 mL of sec-BuLi (1 M/L) was added, followed by stirring at the same temperature for 2 hours. 48.7 g of trimethyl borate having been dissolved in 120 mL of THF was added dropwise thereto at the same temperature, followed by stirring at the same temperature for 1 hour, and the mixture was increased in temperature to room temperature and then stirred over night. Under cooling with an ice bath, 200 mL of 3N hydrochloric acid was added to the mixture. The aqueous layer was extracted with diethyl ether, which was added to the organic layer, and the organic layer was washed with a saturated saline and then dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 48.8 g of 2,3-difluoro-5-methylphenylboric acid (3), which was used in the next step without purification.

출처