반응 #2347

반응 방정식

sodium carbonate

hydrogen bromide

3-benzylbutyrolactone

ethanol

water

→

ethyl 4-benzyl-3-bromobutyrate

반응 조건

후처리

1. 1
   추출The mixture was extracted with ethyl acetate
2. 2
   기타the organic layer filterd through phase separating paper
3. 3
   기타evaporated

실험 절차

A solution of RS 3-benzylbutyrolactone (1.14 g) in ethanol (20 ml) was stirred at 5° C. and gassed for 4 hours with a slow stream of hydrogen bromide. The solution was kept at 5° C. for 20 hours and water (70 ml) added followed by sodium carbonate to neutralise the acid. The mixture was extracted with ethyl acetate and the organic layer filterd through phase separating paper and evaporated to give ethyl 4-benzyl-3-bromobutyrate as an oil; NMR(CDCl3) δ 7.24(5H,m), 4.13(2H,q); 3.45(2H,m), 2.62(2H,d), 2.44(3H,m), 1.25(3H,t); m/e 285(M+H)+.

출처