반응 #2342

반응 방정식

Sodium hydride

4-[4-(4-pyridyl)piperazin-1-yl]phenol

Allyl chloride

→

4-[4-(4-pyridyl)piperazin-1-yl]phenol allyl ether

수율 85.7%

용매

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITcontinued for 20 hours
3. 3
   추출the mixture extracted three times with ethyl acetate
4. 4
   세척The combined extracts were washed with water and brine
5. 5
   건조dried (MgSO4)
6. 6
   기타evaporated
7. 7
   기타The residue was triturated with hexane
8. 8
   여과filtered

실험 절차

Sodium hydride (60% dispersion in mineral oil, 0.4 g) was added to a stirred suspension of 4-[4-(4-pyridyl)piperazin-1-yl]phenol (2.55 g) in DMF (25 ml) and the mixture stirred for 20 minutes at room temperature. Allyl chloride (0.756 g) was added dropwise and stirring continued for 20 hours. Ice-water (75 ml) was added and the mixture extracted three times with ethyl acetate. The combined extracts were washed with water and brine, dried (MgSO4) and evaporated. The residue was triturated with hexane and filtered to give 4-[4-(4-pyridyl)piperazin-1-yl]phenol allyl ether (2.5 g) as a solid;

출처