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1-bromobutane

N-BOC-(R)-2-(3-bromo-4-hydroxybenzyl)morpholine

TFA

intermediate ( a )

N-Boc-(R)-2-(3-(2-(3-pyridinyl)vinyl)-benzyl)morpholine

→

morpholine

(R)-2-(3-Bromo-4-butoxy-benzyl)-morpholine

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후처리

1. 1
   기타Example 61 was prepared

실험 절차

Example 61 was prepared using the same procedure as described for example 4, starting from N-BOC-(R)-2-(3-bromo-4-hydroxybenzyl)morpholine, example 4, intermediate (a), and 1-bromobutane. The resulting intermediate was deprotected with TFA as described for example 4 to yield the desired morpholine example 61 as a colorless oil (28 mg, 63% over 2 steps) after purification by HPLC.

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