반응 #2336533

반응 방정식

2-Methylthiophenol

potassium carbonate

DMF

→

title compound

수율 42.0%

3,6-Bis(2′-methylphenylthio) phthalonitrile

수율 42.0%

반응 조건

후처리

1. 1
   기타The mixture was isolated
2. 2
   기타to give a yellow oil
3. 3
   기타The material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane)

실험 절차

2-Methylthiophenol (10.60 g, 85.5 mmol), potassium carbonate (11.82 g, 82.0 mmol) and ditosylated dicyanohydroquinone (20.00 g, 42.7 mmol) in DMF (75 mL) were reacted as described above. The mixture was isolated as described above to give a yellow oil. The material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane) to give the title compound as a yellow solid (8.85 g, 23.8 mmol, 42%). [Found: C, 70.7%; H, 4.6%; N, 7.5%; S, 17.2%; C22H16N2S2 requires C, 70.9%; H, 4.3%; N, 7.5%; S, 17.2%]; MS (EI+) 372 (M+, 100%), 357 (M-CH3, 8), 339 (20).

출처