반응 #2336526

반응 방정식

4-hydroxypiperidine

phenylpropionyl chloride

phenylpropionic acid

NaOH

→

1-(3-phenylpropionyl)-4-hydroxypiperidine

수율 39.0%

용매

toluene

toluene

반응 조건

후처리

1. 1
   추출the aqueous phase was extracted with CH2Cl2
2. 2
   기타dried
3. 3
   기타evaporated under vacuum

실험 절차

This amine was synthesized in accordance with the method of Scheme 37. To 4 g (40 mmol) of 4-hydroxypiperidine in 20 mL of toluene was added phenylpropionyl chloride (derived from 6 g (40 mmol) of phenylpropionic acid in excess thionyl chloride). To the mixture was added excess 2N aqueous NaOH. After stirring 24 hours, the toluene layer was discarded and the aqueous phase was extracted with CH2Cl2, dried, and evaporated under vacuum to give 3.63 g (39%) of 1-(3-phenylpropionyl)-4-hydroxypiperidine (134). GC/MS indicated 100% purity with a molecular ion of 233.

출처