반응 #2336522
ord-b042792eae154febbebc73d32bd28eb2
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척washed with 5% HCl (20 mL)
- 2건조The organic layer was dried over MgSO4
- 3여과filtered
- 4농축concentrated
- 5기타The residue was purified via flash chromatography
실험 절차
Toluenesulfonyl chloride (397 mg, 2.08 mmol) was added to a 0° C. solution of 7-furyl-3-methyl-4-chromanone oxime (61) (461 mg, 1.89 mmol) and pyridine (0.5 mL) in CH2Cl2 (10 mL). After 6 hours, the mixture was diluted with CH2Cl2 (30 mL) and washed with 5% HCl (20 mL). The organic layer was dried over MgSO4, filtered and concentrated. The residue was purified via flash chromatography using 5:1 hexanes:EtOAc as the eluent, to provide 7-furyl-3-methyl-4-chromanone O-(toluenesulfonyl)-oxime (62) (429 mg) as a pink solid, m.p. 163-164° C. (dec).