반응 #2336521

반응 방정식

Sodium acetate

7-furyl-3-methyl-4-chromanone

hydroxylamine hydrochloride

→

7-furyl-3-methyl-4-chromanone oxime

용매

methanol

반응 조건

후처리

1. 1
   기타The reaction was quenched with H2O
2. 2
   추출extracted with ether (2×25 mL)
3. 3
   건조The combined organic layers were dried over MgSO4
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

Sodium acetate (395 mg, 4.82 mmol) was added portionwise to a solution of 7-furyl-3-methyl-4-chromanone (60) (500 mg, 2.19 mmol) and hydroxylamine hydrochloride (167 mg, 2.41 mmol) in methanol (5 mL), and stirred overnight at room temperature. The reaction was quenched with H2O and extracted with ether (2×25 mL). The combined organic layers were dried over MgSO4, filtered and concentrated to give 7-furyl-3-methyl-4-chromanone oxime (61) as a white solid, m.p. 175-177° C.

출처