반응 #2336518

반응 방정식

Ethyl 4-hydroxypyrimidine-5-carboxylate

LiOH.H2O

→

title compound 19

4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID

용매

THF

MeOH

반응 조건

후처리

1. 1
   기타The mixture was quenched with conc. HCl (1 mL)
2. 2
   추출extracted with EtOAc (2×20 mL)
3. 3
   추출The combined organic extract
4. 4
   건조was dried (MgSO4)
5. 5
   농축concentrated

실험 절차

Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5 mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-HYDROXY-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID (20).

출처