반응 #2335044

반응 방정식

water

acetophenone

sodium hydroxide

4-methyl-3-nitrobenzaldehyde

→

3-(4-methyl-3-nitrophenyl)-1-phenyl-2-propen-1-one

수율 85.6%

용매

ethanol

반응 조건

후처리

1. 1
   기타resulting precipitate
2. 2
   여과was collected by filtration
3. 3
   workup.DISSOLUTIONThe precipitate was dissolved in a mixture of ethyl acetate and tetrahydrofuran
4. 4
   세척The solution was washed with brine
5. 5
   건조dried over magnesium sulfate
6. 6
   농축The solvent was concentrated in vacuo
7. 7
   여과the crystalline residue was collected by filtration

실험 절차

To a solution of acetophenone (7.4 g) and 4N-sodium hydroxide solution (16 ml) in ethanol {60 ml) was added 4-methyl-3-nitrobenzaldehyde (7.4 g) at ambient temperature under stirring and the resultant mixture was stirred at same condition for 1.5 hours. To the reaction mixture was added water and resulting precipitate was collected by filtration. The precipitate was dissolved in a mixture of ethyl acetate and tetrahydrofuran. The solution was washed with brine and dried over magnesium sulfate. The solvent was concentrated in vacuo and the crystalline residue was collected by filtration to give 3-(4-methyl-3-nitrophenyl)-1-phenyl-2-propen-1-one (10.25 g).

출처