반응 #2331992

반응 방정식

4-chloro-1-methyl-3-nitro-1H-[1,8]naphthyridin-2-one

ammonia

→

4-amino-1-methyl-3-nitro-1H-[1,8]naphthyridin-2-one

수율 96.0%

용매

THF

반응 조건

후처리

1. 1
   기타17 h, the solvent was evaporated under reduced pressure and water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   여과The resulting precipitate was filtered
4. 4
   세척washed with water
5. 5
   기타to give

실험 절차

A solution of 4-chloro-1-methyl-3-nitro-1H-[1,8]naphthyridin-2-one (1.54 g, 6.43 mmol) (J. Med. Chem. 1992, 35, 2863-2870) in 40 mL of THF was treated with 7.2 mL of 28% aqueous ammonia (6.4 g, 51 mmol). After stirring at 20° C. 17 h, the solvent was evaporated under reduced pressure and water was added to the residue. The resulting precipitate was filtered and washed with water to give to give 4-amino-1-methyl-3-nitro-1H-[1,8]naphthyridin-2-one (1.35 g, 96% yield). 1H-NMR (DMSO): δ 8.74 (m, 2H), 8.35 (s, 2H), 7.38 (dd, 1H, J=8.0, 4.8 Hz), 3.58 (s, 3H).

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