반응 #2331738

ord-f8ece16a490046869f1ab8ccf68b4570

반응 방정식

C[C@H]1COc2c(F)c(F)cc3c(=O)c(C(=O)O)cn1c23
(S)-(-) 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid
CN1CCNCC1
N-methyl piperazine
C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
levofloxacin
O
water
O
water
→
C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.O
levofloxacin hemihydrate

반응물

C[C@H]1COc2c(F)c(F)cc3c(=O)c(C(=O)O)cn1c23
(S)-(-) 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid
CN1CCNCC1
N-methyl piperazine
C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
levofloxacin
O
water
O
water

시약

없음

용매

CC(C)O
isopropanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타yields crude levofloxacin
  2. 2
    기타followed by precipitation

실험 절차

Accordingly in the present invention reacting (S)-(-) 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid with N-methyl piperazine yields crude levofloxacin. Suspending crude levofloxacin in isopropanol, addition of known quantity of water to make-up the water content to about 12% to about 20% followed by precipitation affords the levofloxacin hemihydrate.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07678903B2uspto-grants-2010_03