반응 #2330539

반응 방정식

[2-amino-5-fluoro-4-(4-methylperhydro-1,4-diazepin-1-yl)phenyl]-amide

9-oxo-9H-fluorene-4-carboxylic acid

→

4-[5-fluoro-6-(4-methyl-perhydro-1,4-diazepin-1-yl)-1H-benzimidazol-2-yl]-9H-fluoren-9-one

용매

acetic acid

반응 조건

후처리

1. 1
   온도In a 100 ml round-bottomed flask under an argon atmosphere, reflux, for 6 hours
2. 2
   기타After purification by formation of a paste with diisopropyl ether

실험 절차

The procedure used in Example 68 is followed. In a 100 ml round-bottomed flask under an argon atmosphere, reflux, for 6 hours, a suspension of 950 mg of [2-amino-5-fluoro-4-(4-methylperhydro-1,4-diazepin-1-yl)phenyl]-amide of 9-oxo-9H-fluorene-4-carboxylic acid, obtained in the previous stage, in 15 ml of acetic acid. After purification by formation of a paste with diisopropyl ether, in this way we obtain 950 mg of 4-[5-fluoro-6-(4-methyl-perhydro-1,4-diazepin-1-yl)-1H-benzimidazol-2-yl]-9H-fluoren-9-one, in the form of an orange powder, which is used as it is in the following stage, with the following characteristics:

출처