반응 #2329

반응 방정식

Bromine

product

methyl 4-(2,2-dimethylacetyl)-phenoxyacetate

→

methyl 4-(2-bromo-2,2-dimethylacetyl)phenoxyacetate

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   기타the solvent was evaporated in vacuo
2. 2
   기타to give an orange oil
3. 3
   여과A solution of this oil, in a small volume of dichloromethane, was filtered through silica
4. 4
   기타the clear filtrate, on evaporation

실험 절차

Bromine (2.09 ml) was added dropwise over ten minutes to a stirred solution of the product of step (i) above (9.44 g) in carbon tetrachloride (200 ml). The solution was stirred for 16 hours, then the solvent was evaporated in vacuo to give an orange oil. A solution of this oil, in a small volume of dichloromethane, was filtered through silica and the clear filtrate, on evaporation, gave methyl 4-(2-bromo-2,2-dimethylacetyl)phenoxyacetate, 11.3 g, as a white crystalline solid: m.p. 46°-50° C.; NMR (d6DMSO) δ 8.09 (2H, d), 7.05 (2H, d), 4.92 (2H, s), 3.72 (3H, s), 2.0(6H, s).

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