반응 #2328975

반응 방정식

trans-4-vinyl cyclohexane carboxylic acid

trimethylsilyl chloride

→

methyl trans-4-vinylcyclohexanecarboxylate

용매

methanol

반응 조건

후처리

1. 1
   온도by refluxing for 6 hours
2. 2
   농축concentrated under reduced pressure
3. 3
   workup.ADDITION150 mL of hexane was added
4. 4
   기타the methanol layer was separated
5. 5
   추출the methanol layer was extracted with hexane
6. 6
   세척the mixture was washed with saturated saline
7. 7
   건조The organic layer was dried over anhydrous sodium sulfate
8. 8
   농축concentrated

실험 절차

All of trans-4-vinyl cyclohexane carboxylic acid was dissolved in 120 mL of methanol and 0.1 g of trimethylsilyl chloride was added, followed by refluxing for 6 hours. The solution was cooling to room temperature and then concentrated under reduced pressure. 150 mL of hexane was added and the methanol layer was separated, and then the methanol layer was extracted with hexane. After combining with the organic layer, the mixture was washed with saturated saline. The organic layer was dried over anhydrous sodium sulfate and then concentrated to obtain 29.5 g of methyl trans-4-vinylcyclohexanecarboxylate.

출처