반응 #2325

반응 방정식

Charcoal

product

4-acetylamino-1-benzylpiperidine

hydrochloric acid

hydrogen

→

4-acetylaminopiperidine hydrochloride

용매

methanol

반응 조건

후처리

1. 1
   기타hydrogenated at room temperature
2. 2
   여과then filtered through diatomaceous earth
3. 3
   기타the filtrate evaporated to dryness

실험 절차

10% w/w Palladium on charcoal (1.5 g) was added to a solution of the product from step (i) (10.0 g), 1 molar hydrochloric acid (21.5 ml) and methanol (150 ml) and the mixture hydrogenated at room temperature and pressure until the theoretical amount of hydrogen had been taken up. Charcoal was added, the mixture stirred for 1 hour then filtered through diatomaceous earth and the filtrate evaporated to dryness giving 4-acetylaminopiperidine hydrochloride, 8.64 g, as a sticky foam: NMR (CDCl3 +d6DMSO). δ 9,72(1H,b), 9.02(1H,b), 7.40(1H,bd), 3.87(1H,m), 3.30(2H,m), 2.81(2H,m), 1.86(4H,m), 1.80(3H,s); m/e 143 (M+H)+.

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